![]() ![]() The SpSCC diagnosis is difficult, especially when it exhibits inconspicuous morphology, inadequate tissue sampling, or association with an exuberant inflammatory reaction. Spindle cell squamous cell carcinoma (SpSCC) is a rare biphasic malignant neoplasm, uncommonly affecting the oral cavity. La connaissance des facteurs de risque, l'examen rigoureux des muqueuses orales, le suivi régulier des patients à risque ainsi que l'amélioration de la formation des chirurgiens-dentistes en cancérologie orale peuvent contribuer à la prévention primaire, au dépistage précoce et à la prise en charge pluridisciplinaire des cancers oraux. Bien que la cavité orale soit facilement accessible à l'examen clinique, les cancers oraux sont diagnostiqués à des stades avancés, d'où le faible taux de survie des patients malgré les avancées thérapeutiques enregistrées au cours des dernières années. ![]() Cependant, ils peuvent apparaître chez des patients sans facteur de risque particulier et sans intoxication chronique alcoolo-tabagique. Leur survenue est liée essentiellement à la consommation de tabac et d'alcool. #Bus simulator 18 exp cheat plusCes cancers sont plus fréquents chez les hommes entre 55 et 65 ans et sont - dans plus de 90 % des cas - des carcinomes épidermoïdes. En France, avec environ 7300 cas incidents et 1700 décès, les cancers oraux occupaient, en 2018, la 12e place parmi les cancers les plus fréquents chez les hommes et la 17e place chez les femmes. Les cancers oraux (incluant les lèvres et la cavité orale) représentaient en 2018 le 16e cancer le plus fréquent au monde avec environ 355 000 nouveaux cas et 177 000 décès. Due to the small number of patients in this study, the findings need to be validated in a larger cohort. Our research results showed that 10 out of 12 patients can match the targeted therapies or immunotherapy currently available in clinical practice or active clinical trials, suggesting precision therapy has the potential utility to improve the long-term prognosis for patients with the rare disease. This was the first study to investigate genomic alterations specifically in Chinese patients with SC of the HN. The TMB value of PIK3CA mutation patients was significantly higher than that of PIK3CA wild-type patients. The tumor mutation burden (TMB) value ranged from 0.71 to 14.71 per megabase, with a median of 4.34. In addition, four patients had mutations in members of the downstream RAS and PI3-kinase pathways, PIK3CA was identified as the most frequently mutated gene in this pathway. Alterations in receptor tyrosine kinases (RTKs) were also found in six patients. Genes related to the cell cycling, chromatin remodeling and histone modification were found to be frequently mutated in patients with SC of the HN. ![]() TP53 was identified as the most frequently mutated gene. Targeted DNA-based next-generation sequencing (NGS) was performed by a 539 genes panel of pan-cancer in 12 patients with SC of the HN to identify their genetic alterations and investigate clinically actionable mutations for use in precision treatment. The genetic background and mechanisms of tumorigenesis remain largely unrevealed, and the progress of precision therapy has been limited. Sarcomatoid carcinoma (SC) of the head and neck (HN) is a rare disease that has both sarcomatoid and cancerous components. Both of these markers are 100% specific for SpCC. Though p63 is a slightly (4%) more sensitive marker than p40, percentage of cell positivity for p40 is higher compared to p63. The sensitivity of p63 is 86% while that of p40 is 82%. IHC of controls showed no immunoreactivity in any of the sarcomas, reactive lesions or spindle cell lesions. value <0.05 considered statistically significant.Īmong 22 cases of SpCC, 19 cases showed positive immunoreactivity to p63, and 18 cases for p40. CK was done for negative cases to prove their epithelial origin. Immunohistochemistry (IHC) was done using Anti-p63 and p40 clone and the results were compared. In this study, histopathologically diagnosed SpCC of head and neck region were considered as cases, and 22 soft tissue sarcomas, reactive lesions and spindle cell lesions of the body were taken as controls. Detection of p63 antigens in SpCC can be helpful however its expression in variousb proliferating soft tissue lesions demands for better marker. This unique biphasic feature on histopathological examination makes its diagnosis problematic. Spindle Cell Carcinoma (SpCC) is a rare type of squamous cell carcinoma (SCC) with prominent malignant spindle cell component. ![]()
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